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Nanomedicine (Lond). 2019 Nov;14(21):2783-2798. doi: 10.2217/nnm-2019-0211. Epub 2019 Oct 16.

Loading AKBA on surface of silver nanoparticles to improve their sedative-hypnotic and anti-inflammatory efficacies.

Author information

1
Natural & Medical Sciences Research Center, University of Nizwa, PO Box 33, Birkat Al Mauz, Nizwa 616, Sultanate of Oman.
2
Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan.
3
Department of Pharmacy, University of Malakand, Lower Dir, Pakistan.
4
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
5
Department of Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.

Abstract

Aim: Acetyl-11-keto-β-boswellic acid (AKBA) is a potent anti-inflammatory compound limited by its low water solubility and bioavailability. To load AKBA on silver nanoparticles (AgNPs) to improve bioavailability and water solubility of the compound. Materials & methods: AKBA-AgNPs were chemically synthesized and characterized by UV-Vis spectrophotometry, Fourier transform infrared spectroscopy, scanning electron microscopy and transmission electron microscopy. AKBA and AKBA-Ag were studied for their sedative-hypnotic and anti-inflammatory efficacies. Results: Pretreatment with AKBA or AKBA-Ag caused significant dose-dependent sedative-hypnotic effects at 5 and 10 mg/kg intraperitoneal. The effects of AKBA-loaded AgNPs caused pronounced changes in mice compared with those of AKBA, and the AKBA-AgNPs demonstrated anti-inflammatory effects that were superior to those of AKBA. Conclusion: The loading of AKBA on nanoparticles improved its pharmacokinetic effects, and capacity for drug delivery.

KEYWORDS:

Boswellia ; AKBA; AKBA-Ag; FTIR; SEM; TEM; acetyl-11-keto-β-boswellic acid; anti-inflammatory effects; heat effect; nanoparticles; optimization; sedative-hypnotic like effects

PMID:
31617445
DOI:
10.2217/nnm-2019-0211

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