Send to

Choose Destination
Nanomedicine (Lond). 2019 Nov;14(21):2783-2798. doi: 10.2217/nnm-2019-0211. Epub 2019 Oct 16.

Loading AKBA on surface of silver nanoparticles to improve their sedative-hypnotic and anti-inflammatory efficacies.

Author information

Natural & Medical Sciences Research Center, University of Nizwa, PO Box 33, Birkat Al Mauz, Nizwa 616, Sultanate of Oman.
Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan.
Department of Pharmacy, University of Malakand, Lower Dir, Pakistan.
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
Department of Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.


Aim: Acetyl-11-keto-β-boswellic acid (AKBA) is a potent anti-inflammatory compound limited by its low water solubility and bioavailability. To load AKBA on silver nanoparticles (AgNPs) to improve bioavailability and water solubility of the compound. Materials & methods: AKBA-AgNPs were chemically synthesized and characterized by UV-Vis spectrophotometry, Fourier transform infrared spectroscopy, scanning electron microscopy and transmission electron microscopy. AKBA and AKBA-Ag were studied for their sedative-hypnotic and anti-inflammatory efficacies. Results: Pretreatment with AKBA or AKBA-Ag caused significant dose-dependent sedative-hypnotic effects at 5 and 10 mg/kg intraperitoneal. The effects of AKBA-loaded AgNPs caused pronounced changes in mice compared with those of AKBA, and the AKBA-AgNPs demonstrated anti-inflammatory effects that were superior to those of AKBA. Conclusion: The loading of AKBA on nanoparticles improved its pharmacokinetic effects, and capacity for drug delivery.


Boswellia ; AKBA; AKBA-Ag; FTIR; SEM; TEM; acetyl-11-keto-β-boswellic acid; anti-inflammatory effects; heat effect; nanoparticles; optimization; sedative-hypnotic like effects


Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center