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Virchows Arch. 2019 Oct 15. doi: 10.1007/s00428-019-02657-y. [Epub ahead of print]

Salivary ghost cell carcinoma: case report and proposal of a new entity.

Author information

1
DERMPATH MÜNCHEN, Munich, Germany. Ihrler@dermpath-muenchen.de.
2
Institute of Pathology, Technical University of Munich, Munich, Germany.
3
Institute of Pathology and Microbiology, Krankenanstalt Rudolfstiftung, Wien, Austria.
4
DERMPATH MÜNCHEN, Munich, Germany.

Abstract

Various topographically heterogeneous, histologically related groups of basaloid tumours are characterized by ghost cell differentiation with associated CTNNB1 mutations and nuclear β-catenin expression. We describe the unique case of a malignant tumour with ghost cell differentiation in the floor of the mouth, in which clinical, radiological, histological, immunohistological and molecular data altogether strongly indicate classification as a new type of salivary gland carcinoma.

KEYWORDS:

CTNNB1; Carcinoma; Ghost cell; Matrical; Salivary gland; β-Catenin

PMID:
31616980
DOI:
10.1007/s00428-019-02657-y

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