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Int J Mol Sci. 2019 Oct 11;20(20). pii: E5052. doi: 10.3390/ijms20205052.

Aquaporins Involvement in Pancreas Physiology and in Pancreatic Diseases.

Author information

1
Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, 1070 Brussels, Belgium. Tatjana.Arsenijevic@erasme.ulb.ac.be.
2
Department of Gastroenterology, Hepatology and Digestive Oncology, Hôpital Erasme, Université Libre de Bruxelles, 808, Route de Lennik, 1070 Brussels, Belgium. Tatjana.Arsenijevic@erasme.ulb.ac.be.
3
Laboratory of Pathophysiological and Nutritional Biochemistry, Université Libre de Bruxelles, 1070 Brussels, Belgium. jason.perret@ulb.ac.be.
4
Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, 1070 Brussels, Belgium. JL.VanLaethem@erasme.ulb.ac.be.
5
Department of Gastroenterology, Hepatology and Digestive Oncology, Hôpital Erasme, Université Libre de Bruxelles, 808, Route de Lennik, 1070 Brussels, Belgium. JL.VanLaethem@erasme.ulb.ac.be.
6
Laboratory of Pathophysiological and Nutritional Biochemistry, Université Libre de Bruxelles, 1070 Brussels, Belgium. cdelport@ulb.ac.be.

Abstract

Aquaporins are a family of transmembrane proteins permeable to water. In mammals, they are subdivided into classical aquaporins that are permeable to water; aquaglyceroporins that are permeable to water, glycerol and urea; peroxiporins that facilitate the diffusion of H2O2 through cell membranes; and so called unorthodox aquaporins. Aquaporins ensure important physiological functions in both exocrine and endocrine pancreas. Indeed, they are involved in pancreatic fluid secretion and insulin secretion. Modification of aquaporin expression and/or subcellular localization may be involved in the pathogenesis of pancreatic insufficiencies, diabetes and pancreatic cancer. Aquaporins may represent useful drug targets for the treatment of pathophysiological conditions affecting pancreatic function, and/or diagnostic/predictive biomarker for pancreatic cancer. This review summarizes the current knowledge related to the involvement of aquaporins in the pancreas physiology and physiopathology.

KEYWORDS:

aquaporins; cancer; pancreas; pancreatitis

PMID:
31614661
DOI:
10.3390/ijms20205052
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Conflict of interest statement

The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript and in the decision to publish the results.

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