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Oncol Lett. 2019 Nov;18(5):4385-4392. doi: 10.3892/ol.2019.10836. Epub 2019 Sep 10.

Role of circular RNA in hematological malignancies.

Mei M1,2, Wang Y1,2, Li Z1,2, Zhang M1,2.

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Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.


Compared with linear RNA, circular RNAs (circRNAs) form a covalently closed circular continuous loop and are highly conserved, stable and tissue-specific. In recent years, circRNAs received considerable attention in the diagnosis, classification, treatment and prognosis of hematological tumors. circRNAs function as microRNA sponges and competitive endogenous RNAs that play an essential role in the translation, regulation and interaction of proteins. The present review discussed the fundamental properties and functions of circRNAs and the latest advancements in the context of circRNAs in the clinical research of hematological malignancies, namely acute and chronic myeloid leukemia, and chronic lymphocytic leukemia. circRNAs show potential in the diagnosis and prognosis of various diseases and can be used as therapeutic targets and biomarkers for disease.


circRNA; hematological tumor; miRNA sponge; tumor biomarker

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