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Indian J Pathol Microbiol. 2019 Oct-Dec;62(4):599-601. doi: 10.4103/IJPM.IJPM_281_19.

Cardiac myxoma with cartilaginous differentiation-An uncommon variant presented as mitral stenosis.

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Department of Pathology, Krishna Institute of Medical Sciences, Deemed University, Karad, Maharashtra, India.
Department of Cardio Vascular and Thoracic Surgery, Krishna Hospital and Medical Research Centre, Karad, Maharashtra, India.


The estimated incidence of primary cardiac tumors is extremely rare. Among it, cardiac myxoma represents the most common benign cardiac tumor constituting about 80% of cases. We are presenting a 30-year-old female with large left atrial myxoma. She was presented with severe dyspnea, palpitations, and systolic murmurs. On 2D echocardiography, left atrial mass obstructing mitral flow was noted. On cardiac magnetic resonance imaging, a single, large, mobile pedunculated mass lesion in left atrium attached to inferior interatrial septum with heterogeneous enhancement was noted, which was likely represented to be myxoma. The mass was surgically excised and valve repairing was done. We received large, solid, lobulated, gray white, soft-to-firm mass measuring 4.5 × 4.1 × 2.5 cm, and on microscopy showed cardiac myxoma with cartilaginous differentiation. We are presenting this case for its clinical, imaging, and uncommon histological features.


Cardiac tumors; cartilaginous differentiation; mitral regurgitation; myxomas


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