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Indian J Pathol Microbiol. 2019 Oct-Dec;62(4):595-598. doi: 10.4103/IJPM.IJPM_713_18.

Type I pleuropulmonary blastoma presenting as congenital pulmonary airway malformation: A report of two cases.

Author information

1
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
2
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
3
Department of Radiology, All India Institute of Medical Sciences, New Delhi, India.
4
Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.

Abstract

Pleuropulmonary blastoma (PPB) is a rare aggressive intrathoracic tumor which is believed to originate from embryonic uncommitted lung mesenchymal cells, which are important for developing the lung. Type I PPB is cystic, type II is cystic and solid, while type III is predominantly solid. Diagnosing type 1 PPB is a challenge for both radiologists as well as pathologists. Owing to its purely cystic nature, type I PPB it is often mistaken for unrelated entities such as congenital pulmonary airway malformation and congenital lobar emphysema which delays surgical intervention. Here, we report two such cases presenting clinically and radiologically as congenital pulmonary airway malformation. On histology, a final diagnosis of type I pleuropulmonay blastoma was made. Thereafter, chemotherapy was administered following complete surgical excision.

KEYWORDS:

Congenital cyst; congenital pulmonary airway malformation; pleuropulmonary blastoma

PMID:
31611448
DOI:
10.4103/IJPM.IJPM_713_18

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