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Indian J Pathol Microbiol. 2019 Oct-Dec;62(4):582-585. doi: 10.4103/IJPM.IJPM_272_19.

Metastatic hepatocellular carcinoma to the parotid gland: A diagnostic dilemma with review of the literature.

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Department of Pathology, Dharamshila Narayana Hospital, New Delhi, India.
Department of Oral and Maxillofacial Pathology, Dharamshila Narayana Hospital, New Delhi, India.


Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy and is a leading cause of cancer-related death worldwide. It has a very aggressive clinical course, with a mean survival rate of much less than a year if left untreated. Here, we present a case of a 68-year-old male with progressively enlarging painful right facial swelling, involving the ramus and condyle of mandible on contrast-enhanced computed tomography mimicking an osteosarcoma. Eventually, the final diagnosis of HCC metastatic to the right parotid gland was made. We report a case of a rare metastasis of HCC to the parotid gland. Furthermore, the present case demonstrates the importance of tissue biopsy and immunohistochemistry for obtaining an accurate final diagnosis.


HepPar-1; Hepatocellular carcinoma; IHC; parotid


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