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Indian J Pathol Microbiol. 2019 Oct-Dec;62(4):556-560. doi: 10.4103/IJPM.IJPM_200_19.

Clinicopathological profile of hepatoblastoma: An experience from a tertiary care center in India.

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Department of Pathology, SRIHER, Chennai, Tamil Nadu, India.
Department of Paediatric Oncology, SRIHER, Chennai, Tamil Nadu, India.
Department of Radiology, SRIHER, Chennai, Tamil Nadu, India.
Department of Paediatric Surgery, SRIHER, Chennai, Tamil Nadu, India.



Hepatoblastoma is the most common primary hepatic malignancy in the pediatric population. Advances in pathological evaluation, imaging, risk stratification, neo-adjuvant chemotherapy, and surgery including transplantation have improved survival of these children in the western countries. However, a successful outcome in developing countries such as India with limited resources poses great challenges to the clinician and the family. Histology plays a major role in determining the prognosis of these patients.


A retrospective study was done on 10 children diagnosed with hepatoblastoma between January 2010 and December 2015 in our institution. Clinical, laboratory, radiological, histopathological diagnoses, treatment, and outcome data were collected and analyzed.


The median age of these children at diagnosis was 11 months, and only 1 child was premature at birth. Most children were presented with abdominal distension. One child had lung metastasis at presentation. Elevated alpha fetoprotein levels were present in 90% of the children. The histological types were fetal, embryonal, macrotrabecular, and mixed epithelial-mesenchymal types. SIOPEL risk stratification was done, which showed 40% of the children to be of high risk. Three children had PRETEXT 1, 2, and 4, respectively.


Our study is significant with respect to the information on PRETEXT staging, risk status, and histological favorability. In developing countries with limited resources and low-socioeconomic status, it is important to have a multidisciplinary team approach and tailor treatment to manage these patients effectively and improve the overall survival.


Alpha fetoprotein; PRETEXT; hepatoblastoma; histology


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