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Environ Int. 2019 Dec;133(Pt A):105118. doi: 10.1016/j.envint.2019.105118. Epub 2019 Oct 11.

Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain.

Author information

1
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; University of Granada, Radiology and Physical Medicine Department, 18016 Granada, Spain; CIBER Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain.
2
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
3
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario San Cecilio de Granada, Spain; CIBER Hepatic and Digestive Diseases (CIBEREHD), 28029 Madrid, Spain. Electronic address: pepileon@ugr.es.
4
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark; International Center for research and research training in Endocrine Disruption of Male Reproduction and Child health (EDMaRC), Rigshospitalet, University of Copenhagen, Denmark.
5
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Escuela Andaluza de Salud Pública, Granada, Spain.
6
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; CIBER Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain; University of Granada, Preventive Medicine and Public Health Department, 18016 Granada, Spain. Electronic address: jparrebola@ugr.es.

Abstract

The aim was to evaluate the associations of environmental phenol and paraben concentrations with the oxidative microenvironment in adipose tissue. This study was conducted in a subsample (n = 144) of the GraMo cohort (Southern Spain). Concentrations of 9 phenols and 7 parabens, and levels of oxidative stress biomarkers were quantified in adipose tissue. Associations were estimated using multivariable linear regression analyses adjusted for potential confounders. Benzophenone-3 (BP-3) concentration was borderline associated with enhanced glutathione peroxidase (GPx) activity [exp(β) = 1.20, p = 0.060] and decreased levels of reduced glutathione (GSH) [exp(β) = 0.55, p = 0.070]. Concentrations of bisphenol A (BPA) and methylparaben (MeP) were associated to lower glutathione reductase (GRd) activity [exp(β) = 0.83, exp(β) = 0.72, respectively], and BPA was borderline associated to increased levels of oxidized glutathione (GSSG) [exp(β) = 1.73, p-value = 0.062]. MeP was inversely associated to both hemeoxygenase-1 (HO-1) and superoxide dismustase (SOD) activity, as well as to the levels of thiobarbituric acid reactive substances (TBARS) [0.75 < exp(β) < 0.79]. Our results suggest that some specific non-persistent pollutants may be associated with a disruption of the activity of relevant antioxidant enzymes, in addition to the depletion of the glutathione stock. They might act as a tissue-specific source of free radicals, contributing to the oxidative microenvironment in the adipose tissue.

KEYWORDS:

Adipose tissue; Environmental phenols; Oxidative stress; Parabens

PMID:
31610369
DOI:
10.1016/j.envint.2019.105118
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