Send to

Choose Destination
J Cell Biochem. 2019 Oct 14. doi: 10.1002/jcb.29392. [Epub ahead of print]

Therapeutic and biological activities of berberine: The involvement of Nrf2 signaling pathway.

Author information

Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Pharmaceutics Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
Central Research Laboratory, Deputy of Research, Kerman University of Medical Sciences, Kerman, Iran.
Department of Basic Science, Shoushtar Branch, Islamic Azad University, Shoushtar, Iran.
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Department of Basic Medical Science, Neyshabur University of Medical Sciences, Neyshabur, Iran.


Since the beginning of the 21st century, studies have focused on developing drugs from naturally occurring compounds. Berberine (Brb) as a plant-derived compound is of interest. It is an isoquinone alkaloid which is derived from Berberis aristata, Berberis aquifolium and Berberis vulgaris. This plant-derived compound has a variety of pharmacological effects such as antioxidant, anti-inflammatory, antidiabetic, antidiarrheal, antitumor, antimicrobial, and anti-inflammatory. Various studies have demonstrated the therapeutic and biological activities of Brb, but there is a lack of a precise review to manifest the signaling pathway of action of Brb. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a highly conserved pathway which mainly involves in preservation of redox balance. At the present review, we describe the therapeutic and biological activities of Brb as well as the relevant mechanisms specially focused on the Nrf2 signaling pathway.


Nrf2 signaling pathway; berberine; cancer therapy; herbal medicine; therapeutic effect


Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center