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Eur J Vasc Endovasc Surg. 2019 Dec;58(6):839-847. doi: 10.1016/j.ejvs.2019.03.025. Epub 2019 Oct 11.

Impact of Stent Graft Design on External Iliac Artery Limb Occlusion Rates After Endovascular Aneurysm Repair: Post-hoc Analysis of a Japanese Multicentre Database.

Author information

1
Department of Vascular Surgery, Shizuoka Red Cross Hospital, Shizuoka, Japan.
2
Department of Surgery, Keio University School of Medicine, Tokyo, Japan. Electronic address: obara.z3@keio.jp.
3
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
4
Department of Surgery, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan.
5
Department of Vascular Surgery, Saiseikai Yokohamashi Tobu Hospital, Kawasaki, Japan.
6
Department of Surgery, Kawasaki Municipal Hospital, Kawasaki, Japan.
7
Department of Surgery, Tokyo Medical Centre, Tokyo, Japan.
8
Department of Surgery, Mito Red Cross Hospital, Mito, Japan.
9
Department of Surgery, Saitama Municipal Hospital, Saitama, Japan.
10
Department of Surgery, Saitama Municipal Hospital, Saitama, Japan; Department of Surgery, Hiratsuka City Hospital, Hiratsuka, Japan.
11
Department of Surgery, Saiseikai Central Hospital, Tokyo, Japan.
12
Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.

Abstract

OBJECTIVE/BACKGROUND:

It was hypothesised that a helical stent with expanded polytetrafluoroethylene (ePTFE) grafts could provide a preventive effect for external iliac artery (EIA) limb occlusion following endovascular aortic aneurysm repair (EVAR). Therefore, a post-hoc analysis of a Japanese multicentre database was conducted to assess the impact of the stent graft design on EIA limb occlusion rates.

METHODS:

Patients who underwent EVAR with EIA limb deployment between 2008 and 2016 were evaluated. The stent graft limbs were divided into two groups: group A comprised stent graft limbs made of a helical stent with ePTFE grafts (Excluder; n = 255), and group B comprised stent graft limbs made of a Z stent with polyester grafts (Zenith, Flex and Endurant; n = 173). The main outcome was the incidence of limb occlusion and severe limb stenosis (EIA related limb complications). The risk factors for EIA related limb complications were analysed and the midterm results between groups A and B compared. Fine-Gray generalisation of the proportional hazards model was used after propensity score matching to calculate the hazard ratio (HR).

RESULTS:

One complication occurred in group A and 10 complications occurred in group B. The risk factors for EIA related limb complications for the entire group were a stent graft limb size ≤10 mm (HR 5.41; p = .01) and inclusion in group B (HR 14.9; p = .009). After propensity matching, group A (n = 159) was matched with group B (n = 159). The cumulative incidence function of EIA related limb complications at five years was 0.66% in group A and 7.8% in group B (HR 8.67; p = .039).

CONCLUSION:

Stent graft design can affect limb patency in EIA limb deployment. When EIA limb deployment is necessary for patients with a small EIA, such as Japanese patients, stent graft limbs made of a helical stent with ePTFE should be used to reduce the risk of limb occlusion.

KEYWORDS:

Abdominal aortic aneurysm; EIA limb occlusion; Endovascular aortic aneurysm repair; Japanese

PMID:
31607678
DOI:
10.1016/j.ejvs.2019.03.025

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