Format

Send to

Choose Destination
Trends Microbiol. 2019 Oct 8. pii: S0966-842X(19)30218-5. doi: 10.1016/j.tim.2019.08.005. [Epub ahead of print]

The Case for Modeling Human Infection in Zebrafish.

Author information

1
Department of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
2
Department of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. Electronic address: serge.mostowy@lshtm.ac.uk.

Abstract

Zebrafish (Danio rerio) larvae are widely recognized for studying host-pathogen interactions in vivo because of their optical transparency, genetic manipulability, and translational potential. The development of the zebrafish immune system is well understood, thereby use of larvae enables investigation solely in the context of innate immunity. As a result, infection of zebrafish with natural fish pathogens including Mycobacterium marinum has significantly advanced our understanding of bacterial pathogenesis and vertebrate host defense. However, new work using a variety of human pathogens (bacterial, viral, and fungal) has illuminated the versatility of the zebrafish infection model, revealing unexpected and important concepts underlying infectious disease. We propose that this knowledge can inform studies in higher animal models and help to develop treatments to combat human infection.

KEYWORDS:

antibiotic resistance; bacterial cell biology; cell-autonomous immunity; cellular microbiology; host defense; pathogenesis; zebrafish

PMID:
31604611
DOI:
10.1016/j.tim.2019.08.005
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center