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Science. 2019 Sep 20;365(6459). pii: eaaw1944. doi: 10.1126/science.aaw1944.

Global trends in antimicrobial resistance in animals in low- and middle-income countries.

Author information

1
Institute for Environmental Decisions, ETH Zurich, Zurich, Switzerland. thomas.vanboeckel@env.ethz.ch.
2
Center for Disease Dynamics, Economics and Policy, New Delhi, India.
3
Institute for Integrative Biology, ETH Zurich, Zurich, Switzerland.
4
Institute for Environmental Decisions, ETH Zurich, Zurich, Switzerland.
5
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
6
Princeton Environmental Institute, Princeton University, Princeton, NJ, USA.
7
Université Libre de Bruxelles (ULB), Brussels, Belgium.
#
Contributed equally

Abstract

The global scale-up in demand for animal protein is the most notable dietary trend of our time. Antimicrobial consumption in animals is threefold that of humans and has enabled large-scale animal protein production. The consequences for the development of antimicrobial resistance in animals have received comparatively less attention than in humans. We analyzed 901 point prevalence surveys of pathogens in developing countries to map resistance in animals. China and India represented the largest hotspots of resistance, with new hotspots emerging in Brazil and Kenya. From 2000 to 2018, the proportion of antimicrobials showing resistance above 50% increased from 0.15 to 0.41 in chickens and from 0.13 to 0.34 in pigs. Escalating resistance in animals is anticipated to have important consequences for animal health and, eventually, for human health.

PMID:
31604207
DOI:
10.1126/science.aaw1944

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