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Rev Environ Health. 2019 Dec 18;34(4):403-414. doi: 10.1515/reveh-2019-0052.

Arsenic exposure with reference to neurological impairment: an overview.

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Former ICMR-PDF, ICMR-NIOH, Ahmedabad, India.
A-10 Radhey Kunj Apartment, Shahibaug, Ahmedabad 380004, India.
Former Director-in-Charge, National Institute of Occupational Health (ICMR), Ahmedabad 380016, India.


Arsenic (As) toxicity has become a public health and environmental problem, which is a serious issue in certain parts of the world. Many people are exposed to As through contaminated drinking water, food and soil, through occupation, etc. Chronic As exposure is linked to various hostile health effects including skin problems, cancer, diabetes, cardiovascular disease, reproductive and developmental and neurological problems in exposed subjects. Experimental existing data indicate that chronic As exposure affects the nervous system by impairing the nerve and brain tissues of the exposed animals, and clinical studies indicate that As exposure leads to both central nervous system and peripheral nervous system impairments and also causes depression, memory impairment and difficulty in problem solving, affects body coordination, etc. Various prenatal and postnatal studies with respect to As exposure also suggest that developing offspring and young children are susceptible to As exposure. The only solution to this serious health problem is to stop occupational As exposure and provide As free drinking water to the affected population.


arsenic; central nervous system; cognitive; coordination; memory impairments; neurological disorder


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