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J Cancer Res Ther. 2019 Jul-Sep;15(5):1062-1066. doi: 10.4103/jcrt.JCRT_553_17.

Thiol-disulfide homeostasis in breast cancer patients.

Author information

1
Department of General Surgery, Training and Research Hospital, University of Health Sciences, Konya, Turkey.
2
Department of Anesthesiology, Training and Research Hospital, University of Health Sciences, Konya, Turkey.
3
Department of Family Medicine, Training and Research Hospital, University of Health Sciences, Konya, Turkey.
4
Department of Biochemistry, Training and Research Hospital, University of Health Sciences, Konya, Turkey.
5
Department of Biochemistry, Yildirim Beyazit University, Ankara Atatürk Training and Research Hospital, Ankara, Turkey.

Abstract

Objective:

The aim of our study is to assess thiol-disulfide homeostasis (TDH), which is a biomarker of systemic oxidative stress, in breast cancer patients.

Materials and Methods:

Thirty-seven breast cancer patients and 31 age-matched healthy volunteers were enrolled in this study. Serum native thiol, disulfide, and total thiol levels and disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were analyzed using a novel colorimetric method.

Results:

Serum native thiol level was statistically significantly lower in breast cancer patients (350.39 ± 7.15) than in healthy controls (380.60 ± 7.35) (P = 0.008). Serum disulfide level was statistically significantly higher in breast cancer patients (24.96 ± 0.85) than in healthy controls (19.25 ± 1.34) (P = 0.002).

Conclusion:

To our knowledge, this study is the first study in the literature that investigated TDH in breast cancer patients. We have concluded that an alteration in TDH due to oxidative stress is likely to have a role in the pathogenesis of breast cancer.

KEYWORDS:

Breast cancer; oxidative stress; thiol-disulfide homeostasis

PMID:
31603111
DOI:
10.4103/jcrt.JCRT_553_17
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