Format

Send to

Choose Destination
J Intern Med. 2019 Oct 11. doi: 10.1111/joim.12987. [Epub ahead of print]

Leisure-time physical activity and life expectancy in people with cardiometabolic multimorbidity and depression.

Author information

1
From the, Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, UK.
2
Leicester Diabetes Centre, National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care - East Midlands (CLAHRC-EM, Leicester, UK.
3
Leicester Diabetes Centre, NIHR Leicester Biomedical Research Centre, Leicester, UK.
4
Alliance for Research in Exercise, Nutrition and Activity (ARENA), Division of Health Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia.

Abstract

BACKGROUND:

Whether and to what extent leisure-time physical activity at the recommended levels of 150-min moderate activity is associated with survival in people with cardiometabolic multimorbidity and depression is unknown.

METHODS:

UK Biobank participants were classified into groups: (i) no disease; (ii) diabetes; (iii) cardiovascular disease (CVD); (iv) depression; (v) diabetes and CVD; (vi) diabetes and depression; (vii) CVD and depression; (viii) diabetes, CVD and depression. Leisure-time physical activity was categorized as active (meeting recommendations) or inactive. Survival models were applied to estimate life expectancy.

RESULTS:

A total of 480 940 participants were included (median age, 58 years; 46% men; 95% white), of whom 74% with cardiometabolic multimorbidity and depression were inactive. During a mean follow-up of 7 years, 11 006 deaths occurred. At age of 45 years, being physically active was associated with 2.34 (95% confidence interval: 0.93, 3.54) additional years of life compared with being inactive in participants with diabetes; corresponding estimates were 2.28 (1.40, 3.16) for CVD; 2.15 (0.05, 4.26) for diabetes and CVD; and 1.58 (1.27, 1.89) for no disease. Participants with a combination of diabetes, CVD and depression, being active was associated with 6.81 (-1.50, 15.31) additional years compared with being inactive; corresponding estimates were 3.07 (-2.46, 8.59) for diabetes and depression; 2.34 (-1.24, 5.91) for CVD and depression; and 0.80 (-0.46, 2.05) for depression. A similar pattern was found at 65 years.

CONCLUSIONS:

Meeting the recommended level of physical activity was associated with a longer life expectancy in people with cardiometabolic multimorbidity but not in those with depression.

KEYWORDS:

UK biobank; cardiometabolic multimorbidity; depression; leisure-time physical activity; life expectancy

PMID:
31602698
DOI:
10.1111/joim.12987

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center