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Methods Mol Biol. 2019;2049:213-231. doi: 10.1007/978-1-4939-9736-7_13.

Probing the RNA-Binding Proteome from Yeast to Man: Major Advances and Challenges.

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Molecular Infection Biology, IRI Life Sciences, Humboldt-Universit├Ąt zu Berlin, Berlin, Germany.
Centre for Systems and Synthetic Biology (SynthSys), University of Edinburgh, Edinburgh, UK.


RNA-binding proteins are important for core cellular processes such as mRNA transcription, splicing, transport, translation, and degradation. Recently, hundreds of novel RNA-binders have been identified in vivo in various organisms and cell types. We discuss the RNA interactome capture technique which enabled this boost in identifying new RNA-binding proteins in eukaryotes. A focus of this chapter, however, is the presentation of different challenges and problems that need to be addressed to be able to understand the conserved mRNA-bound proteomes from yeast to man.


Eukaryotes; Proteome; RNA-binding proteins; mRNA processing

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