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Anesth Essays Res. 2019 Jul-Sep;13(3):471-475. doi: 10.4103/aer.AER_100_19.

Intrathecal 1% 2-Chloroprocaine with Fentanyl in Comparison with Ropivacaine (0.5%) with Fentanyl in Day Care Perianal Surgery: Prospective Randomized Comparative Study.

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Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.



Spinal anesthesia is a reliable and safe technique for perianal surgeries; the changing trend of surgical practice from an inpatient to outpatient has urged us to use lower dose of local anesthetic providing segmental block with adjuvants such as opioids. Ropivacaine is a long acting; amide local anesthetic, with greater sensory motor differentiation. Chloroprocaine (CP) is an amino-ester local anesthetic with a very short half-life. This study was designed to compare CP with ropivacaine for spinal anesthesia in an elective ambulatory setting.


This prospective, randomized, comparative study included 60 adult patients scheduled to undergo perianal surgeries under subarachnoid block with intrathecal 3.0 mL of 1% CP with 12.5 μg fentanyl (Group C) or 1.5 mL of 0.5% ropivacaine with 12.5 μg fentanyl (Group R).

Statistical Analysis:

Chi-square test used to assess significance for qualitative data, independent t-test for significance of the mean difference between two quantitative variables.


Meantime of onset of sensory block at T10 in both the groups were comparable (Group C - 4.7 min, Group R - 4.8 min). Maximum upper level of sensory block was at T8 in both the groups, time for regression of sensory level to L1 was significantly longer with ropivacaine (Group R - 135 min, Group C - 76 min, P < 0.0001), and the duration of motor blockade (Group C - 81 min, Group R - 145 min P < 0.0001) was significantly short in the Group C with early ambulation (160 min).


CP provides adequate duration and depth of surgical anesthesia for short procedures with the advantages of faster block resolution and earlier hospital discharge compared with spinal ropivacaine.


Adjuvants; fentanyl; ropivacaine

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