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Elife. 2019 Oct 9;8. pii: e47021. doi: 10.7554/eLife.47021.

Modular organization of cerebellar climbing fiber inputs during goal-directed behavior.

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Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
CREST, Japan Science and Technology Agency, Saitama, Japan.
Department of Neurophysiology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Brain Science Institute, Tamagawa University, Tokyo, Japan.
Department of Physiology and Cell Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Cellular and Molecular Physiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.
International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo, Japan.


The cerebellum has a parasagittal modular architecture characterized by precisely organized climbing fiber (CF) projections that are congruent with alternating aldolase C/zebrin II expression. However, the behavioral relevance of CF inputs into individual modules remains poorly understood. Here, we used two-photon calcium imaging in the cerebellar hemisphere Crus II in mice performing an auditory go/no-go task to investigate the functional differences in CF inputs to modules. CF signals in medial modules show anticipatory decreases, early increases, secondary increases, and reward-related increases or decreases, which represent quick motor initiation, go cues, fast motor behavior, and positive reward outcomes. CF signals in lateral modules show early increases and reward-related decreases, which represent no-go and/or go cues and positive reward outcomes. The boundaries of CF functions broadly correspond to those of aldolase C patterning. These results indicate that spatially segregated CF inputs in different modules play distinct roles in the execution of goal-directed behavior.


cerebellum; climbing fiber; go/no-go task; mouse; neuroscience

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