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Curr Mol Med. 2019 Oct 9. doi: 10.2174/1566524019666191009150734. [Epub ahead of print]

Change in quality of life of OSAHS patients with minimally invasive surgery or CPAP therapy: A 2-year retrospective, single-center parallel group study.

Author information

1
Sleep Medicine Center, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan. China.
2
Yangzhou Health Supervision Institute. China.

Abstract

BACKGROUND:

This study took the untreated OSAHS patients as the control group, exploring the influence of minimally invasive surgery treatment and CPAP therapy on OSAHS patients, subjective and objective performance, discussing their relationship, finding out the effect factor and providing a simple and practical evaluation of clinical efficacy.

METHODS:

Choose 90 OSAHS patients diagnosed in the Sleep Disorders Diagnosis and Treatment Center of Sichuan Province from May 2014 to May 2016,divide into surgery group, CPAP group and untreated group,then follow up in six month、1year、2year respectively. Compare three groups, physiological indicators, clinical symptoms, the degree of daytime sleepiness and quality of life, evaluate the daytime sleepiness and quality of life changes before and after minimally invasive surgery and CPAP treatment, explore the subjective and objective efficacy of surgery and CPAP treatment.

RESULTS:

In the 90 patients,11(12.2%) had the hypertension, 2(2.2%) had the diabetes. The average AHI was 50.53±23.39 per hour,and the mean minimum oxygen saturation and mean oxygen saturation was 71.25±14.16%,90.13±5.90% respectively; There were statistical significant in mouth breathing、morning throat、daytime sleepiness in surgery group at 0.5 year and 1year; In CPAP group,there were statistical significant in mouth breathing、morning throat、daytime sleepiness at 0.5 year、1year and 2year, there was statistical significant in memory loss at 1year and 2year, there was statistical significant in frequent nocturia at 1year; The ESS value in surgery group decreased at 0.5y and 1y,but increased at 2year.The situation was the same in total points and each dimension of SF-36; The delta values of ESS among three groups had statistical significant at 0.5year、1year and 2year, and CPAP group changed the most, followed by surgery group and healthy education group.

CONCLUSIONS:

All the minimally invasive surgery、CPAP therapy and healthy education can improve the daytime sleepiness and quality of life, CPAP therapy changed the most, followed by minimally invasive surgery and healthy education. But the treatment of OSAHS should be comprehensive.

KEYWORDS:

CPAP; Minimally invasive surgery; OSAHS; Quality of life

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