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J Cereb Blood Flow Metab. 2019 Dec;39(12):2536-2538. doi: 10.1177/0271678X19881449. Epub 2019 Oct 8.

Delayed recanalization in acute ischemic stroke patients: Late is better than never?

Author information

1
Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
2
Department of Physiology, School of Medicine, Loma Linda University, Loma Linda, USA.

Abstract

Successful recanalization of the occluded vessel as early as possible has been widely accepted as the key principle of acute ischemic stroke (AIS) treatment. Unfortunately, for many years, the vast majority of AIS patients were prevented from receiving effective recanalization therapy because of a narrow therapeutic window. Recently, a series of inspiring clinical trials have indicated that more patients may benefit from delayed recanalization during an expanded therapeutic window, even up to 24 h after symptom onset. However, could potentially salvageable brain tissue (penumbra) in patients who do not receive medication within 24 h still possible to be saved?

KEYWORDS:

Acute ischemic stroke; clinical trials; delayed recanalization; penumbra; therapeutic window

PMID:
31594437
PMCID:
PMC6893989
[Available on 2020-12-01]
DOI:
10.1177/0271678X19881449

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