Format

Send to

Choose Destination
Phys Med Biol. 2019 Oct 8. doi: 10.1088/1361-6560/ab4c27. [Epub ahead of print]

The importance of dead material within a tumour on the dynamics in response to radiotherapy.

Author information

1
University of Oxford, Oxford, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
2
Moffitt Cancer Center, Tampa, Florida, UNITED STATES.
3
Department of Radiation Oncology and Radiology, Moffitt Cancer Center, Tampa, UNITED STATES.
4
Integrated Mathematical Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, SRB-4, Tampa, Florida, 33612, UNITED STATES.

Abstract

In vivo tumours are highly heterogeneous, often comprising regions of hypoxia and necrosis. Radiotherapy significantly alters the intratumoural composition. Moreover, radiation-induced cell death may occur via a number of different mechanisms that act over different timescales. Dead material may therefore occupy a significant portion of the tumour volume for some time after irradiation and may affect the subsequent tumour dynamics. We present a three phase tumour growth model that accounts for the effects of radiotherapy and use it to investigate how dead material within the tumour may affect the spatio-temporal tumour response dynamics. We use numerical simulation of the model equations to characterise qualitatively different tumour volume dynamics in response to fractionated radiotherapy. We demonstrate examples, and associated parameter values, for which the properties of the dead material significantly alter the observed tumour volume dynamics throughout treatment. These simulations suggest that for some cases it may not be possible to accurately predict radiotherapy response from pre-treatment, gross tumour volume measurements without consideration of the dead material within the tumour.

KEYWORDS:

cell death; fractionated radiotherapy; moving boundaries; multiphase mixtures; tumour growth

PMID:
31593931
DOI:
10.1088/1361-6560/ab4c27

Supplemental Content

Full text links

Icon for IOP Publishing Ltd.
Loading ...
Support Center