Format

Send to

Choose Destination
Hum Vaccin Immunother. 2019 Oct 7. doi: 10.1080/21645515.2019.1674598. [Epub ahead of print]

Attitudes, knowledge, and willingness to be vaccinated against seasonal influenza among patients hospitalized with Influenza-Like-Illness: impact of diagnostic testing.

Tubiana S1,2, Launay O3,4,5, Galtier F5,6, Tattevin P5,7, Postil D5,8, Vanhems P5,9, Lanzi N5, Verger P5,10,11, Duval X1,2,5.

Author information

1
Inserm CIC1425 Bichat, Hôpital Bichat-Claude Bernard, Assistance Publique-Hôpitaux de Paris (AP-HP) , Paris , France.
2
IAME, UMR1137, Sorbonne Paris Cité , F-75018 Paris , France.
3
Université Paris Descartes, Sorbonne Paris Cité, Inserm , CIC 1417, Paris, France, Paris , France.
4
Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Cochin, CIC Cochin Pasteur Paris , France.
5
Inserm, F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) , Paris , France.
6
CIC 1411, Hôpital Saint-Eloi, CHU de Montpellier , Montpellier , France.
7
Hôpital Pontchaillou, INSERM U835, Faculté de Médecine, Université Rennes 1 , IFR140 , Rennes.
8
CIC de Limoges, CHU Dupuytren, Limoges , Limoges , France.
9
Service d'Hygiène, Epidémiologie et Prévention, Groupement Hospitalier Edouard Herriot, Lyon, and Emerging Pathogens Laboratory - Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI) Inserm U1111 , CNRS UMR5308, ENS de Lyon, UCBL1, 69007 Lyon , France.
10
UMR VITROME (Vecteurs, Infections TROpicales et MEditerranéennes), Aix Marseille Univ, INSERM, IRD , Marseille , France.
11
ORS PACA, Observatoire Régional de la Santé Provence-Alpes-Côte d׳Azur , Marseille , France.

Abstract

Influenza vaccine adherence remains low. Communication of virological diagnosis to adults hospitalized with influenza-like illness (ILI) could improve their willingness to be subsequently vaccinated. We prospectively assessed, in adults hospitalized with ILI in six French university hospitals, their willingness to be vaccinated against influenza in the subsequent season, both before and after the communication of RT-PCR Influenza laboratory result; we identified then the determinants associated with the willingness to be vaccinated. A total of 309 patients were included during the 2012-2013 and 2013-2014 influenza seasons; 43.8% reported being vaccinated against influenza for the current season; before communication of influenza laboratory results, 65.1% reported willingness to be vaccinated during the subsequent season. Influenza was virologically confirmed in 103 patients (33.3%). The rate of vaccine willingness increased to 70.4% (p=0.02) after communication of influenza laboratory results. Factors independently associated with the willingness to be vaccinated were the perception of influenza vaccine benefits (adjusted relative risk (aRR): 1.06, 95%CI 1.02-1.10), cues to action (aRR: 1.08, 95%CI 1.03-1.12), current season influenza vaccination (aRR: 1.38, 95%CI 1.20-1.59) and communication of a positive influenza laboratory result (aRR: 1.18, 95%CI 1.03-1.34). This last was associated with the willingness to be vaccinated only in the subpopulation of patients not vaccinated (aRR: 1.53, 95%CI 1.19-1.96). In patients hospitalized with ILI, communication of a positive influenza diagnostic led to a better appreciation of the disease's severity and increased the willingness to be vaccinated. This approach might be particularly beneficial in patients who do not have a history of influenza vaccination.

KEYWORDS:

Influenza; Influenza-like illness; Seasonal influenza vaccine; willingness

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center