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Curr Drug Metab. 2019 Oct 7. doi: 10.2174/1389200220666191007154723. [Epub ahead of print]

Current Designs and Developments of Fucoidan-Based Formulations for Cancer Therapy.

Author information

1
Deakin University, School of Medicine, Geelong. Australia.
2
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City. Vietnam.

Abstract

BACKGROUND:

Natural nanostructure materials have been involved in antitumor drug delivery systems due to their biocompatibility, biodegradation and bioactive properties.

METHODS:

These materials have contributed to advanced drug delivery systems in the roles of both bioactive compounds and delivery nanocarriers. Fucoidan, a valuable ocean material used in drug delivery systems, has been exploited in research on cancer and a variety of other diseases.

RESULTS:

Although the uniqueness, structure, properties and health benefits of fucoidan have been mentioned in various prominent reviews, current developments and designs of fucoidan-based formulations still need to be assessed to further develop an effective anticancer therapy. In this review, current important formulations using fucoidan as a functional material and as an anticancer agent will be discussed. This article will also provide a brief principle of the methods that incorporate functional nanostructure materials in formulations exploiting fucoidan.

CONCLUSION:

Current research and future perspectives on the use of fucoidan in anticancer therapy will advance innovative and important products for clinical uses.

KEYWORDS:

Fucoidan; anticancer; drug delivery system; functional nanomaterials; nanocarriers; nanotechnology

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