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Nucleosides Nucleotides Nucleic Acids. 2019 Oct 7:1-17. doi: 10.1080/15257770.2019.1674333. [Epub ahead of print]

Synthesis of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their monophosphate prodrugs.

Author information

1
Department of Medicinal Biotechnology, Dong-A University , Busan , South Korea.
2
Department of Pediatics, Emory University , Atlanta , GA , USA.

Abstract

Novel 7-trifluoromethyl-7-deazapurine ribonucleoside analogs (13a-c) and their Protides (15a-c) were successfully synthesized from ribolactol or 1-α-bromo-ribose derivatives using Silyl-Hilbert-Johnson or nucleobase-anion substitution reactions followed by key aromatic trifluoromethyl substitution. Newly prepared compounds were evaluated against a panel of RNA viruses, including HCV, Ebola or Zika viruses.

KEYWORDS:

7-trifluoromethyl-7-deazapurine ribonucleoside; RNA viruses; Silyl-Hilbert-Johnson; protides

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