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Cell Prolif. 2019 Oct 6:e12698. doi: 10.1111/cpr.12698. [Epub ahead of print]

Long non-coding RNAs in cutaneous biology and proliferative skin diseases: Advances and perspectives.

Author information

1
Department of Pharmacology of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
2
School of Bioscience and Bio-pharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China.
3
Guangzhou Virotech Pharmaceutical Co., Ltd, Guangzhou, China.
4
Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Abstract

Advances in transcriptome sequencing have revealed that the genome fraction largely encodes for thousands of non-coding RNAs. Long non-coding RNAs (lncRNAs), which are a class of non-protein-coding RNAs longer than approximately 200 nucleotides in length, are emerging as key epigenetic regulators of gene expression recently. Intensive studies have characterized their crucial roles in cutaneous biology and diseases. In this review, we address the promotive or suppressive effects of lncRNAs on cutaneous physiological processes. Then, we focus on the pathogenic role of dysfunctional lncRNAs in a variety of proliferative skin diseases. These evidences suggest that lncRNAs have indispensable roles in the processes of skin biology. Additionally, lncRNAs might be promising biomarkers and therapeutic targets for cutaneous disorders.

KEYWORDS:

cutaneous squamous cell carcinoma; keratinocyte differentiation; long non-coding RNAs; melanoma; psoriasis; wound healing

PMID:
31588640
DOI:
10.1111/cpr.12698

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