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Ginekol Pol. 2019;90(9):513-519. doi: 10.5603/GP.2019.0089.

Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary.

Author information

1
Kartal Dr Lutfi Kirdar Training and Research Hospital, Kartal, Istanbul, Turkey. sakin-onder@hotmail.com.
2
Kartal Dr Lutfi Kirdar Training and Research Hospital, Kartal, Istanbul, Turkey.

Abstract

OBJECTIVES:

The aim of this study was to compare the effects of sildenafil, vardenafil and tadalafil in treatment for ischemia/reperfusion injury which is created experimentally in rat ovaries.

MATERIAL AND METHODS:

For this study, 30 female Wistar albino rats were used, and the rats were separated randomly intofive groups consisting of six rats each: normal, torsion-detorsion, torsion-detorsion + sildenafil 1.4 mg/kg, torsion-detorsion+ vardenafil 1.7 mg/kg and torsion-detorsion + tadalafil 5.0 mg/kg. The agents were given intraperitoneally 30 minutesbefore detorsion. An ovarian torsion procedure was implemented in all other groups for 3 hours with the exception of thenormal group. Then, a detorsion procedure was implemented to the groups for 3 hours.

RESULTS:

The sildenafil and vardenafil treatments showed protective effect by preventing significant increase in inflammationparameters. (p = 0.058, 0.138). The tadalafil treatment was only protective for cellular degeneration (p = 0.140). Thevardenafil treatment was protective for edema (p = 0.238), vascular congestion (p = 0.111), inflammation (p = 0.138) andcellular degeneration (p = 0.532). Sildenafil, vardenafil and tadalafil inhibited the increase of atretic follicle. AMH levels werestatistically different between torsion and detorsion and vardenafil group (p = 0.004, 0.004), whereas tadalafil and sildenafilgroups were similar to normal group (p = 0.108, 0.108).

CONCLUSIONS:

PDE inhibitors were found to be effective in reducing ovarian ischemia/reperfusion injury. Sildenafil andtadalafil seem to be more effective than the vardenafil in protecting the ovarian reserve.

KEYWORDS:

adnexal torsion; ischemia-reperfusion injury; rat model; sildenafil; tadalafil; vardenafil

PMID:
31588548
DOI:
10.5603/GP.2019.0089
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