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Exp Suppl. 2019;111:419-441. doi: 10.1007/978-3-030-25905-1_19.

Genetics of Obesity.

Author information

1
Obesity Center CGG, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
2
Department of Clinical Genetics, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
3
Department of Clinical Genetics, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands.
4
Obesity Center CGG, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. e.l.t.vandenakker@erasmusmc.nl.
5
Division of Endocrinology, Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands. e.l.t.vandenakker@erasmusmc.nl.

Abstract

Obesity is caused by an imbalance between energy intake and output, influenced by numerous environmental, biological, and genetic factors. Only a minority of people with obesity have a genetic defect that is the main cause of their obesity. A key symptom for most of these disorders is early-onset obesity and hyperphagia. For some genetic obesity disorders, the hyperphagia is the main characteristic, often caused by disruptions of the leptin-melanocortin pathway, the central pathway that regulates the body's satiety and energy balance. For other disorders, obesity is part of a distinct combination of other clinical features such as intellectual disability, dysmorphic facial features, or organ abnormalities. This chapter focuses on genetic obesity disorders and also summarizes the present knowledge on the genetics of the more common polygenic/multifactorial obesity.

KEYWORDS:

Body weight regulation; Common obesity; Early-onset obesity; Genetic obesity; Hyperphagia; Leptin-melanocortin pathway; Non-syndromic obesity; Syndromic obesity

PMID:
31588542
DOI:
10.1007/978-3-030-25905-1_19
[Indexed for MEDLINE]

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