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J Pharmacol Sci. 2019 Sep 13. pii: S1347-8613(19)35706-8. doi: 10.1016/j.jphs.2019.09.004. [Epub ahead of print]

Involvement of l-lactate in hippocampal dysfunction of type I diabetes.

Author information

1
Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
2
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
3
Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: ohsawa@phar.nagoya-cu.ac.jp.

Abstract

Hippocampal neurons play a crucial role in memory formation. Accumulating evidence raises the possibility that hippocampal sharp-wave ripples (SW-Rs) are involved in memory consolidation. Here, we examined in an animal model of diabetes and found the amplitude of SW-Rs in diabetic mice were smaller than control group and were rescued by acute application of l-lactate, a major neural energy source. The cognitive impairment in diabetic mice was alleviated by intracerebroventricular l-lactate treatment. Our results suggested that l-lactate is important for hippocampal dysfunction in diabetes.

KEYWORDS:

Cognitive impairment; Diabetes mellitus; Sharp wave ripples (SW-Rs)

PMID:
31586517
DOI:
10.1016/j.jphs.2019.09.004
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