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Med Phys. 2019 Oct 4. doi: 10.1002/mp.13851. [Epub ahead of print]

Voxel-based dosimetry is superior to mean-absorbed dose approach for establishing dose-effect relationship in targeted radionuclide therapy.

Author information

1
Nuclear Medicine Division, Foundation IRCCS Istituto Nazionale Tumori, 20133, Milan, Italy.
2
Centre de Recherches en Cancérologie de Toulouse, Université Paul Sabatier, UMR 1037 INSERM, Toulouse, France.
3
Geneva University Hospital, Geneva, Switzerland.

Abstract

It is becoming evident that patient-individualized dosimetry in targeted radionuclide therapy (TRT) is a must and not a luxury in the era of precision medicine. It's often argued that patient-specific absorbed dose assessment should be the standard and become routine in TRT, similar to other forms of radiation therapy to improve the correlations between the administered activitiy and the clinical outcome and enable better understanding of the absorbed dose-response relationship.

PMID:
31584697
DOI:
10.1002/mp.13851

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