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J Indian Soc Pedod Prev Dent. 2019 Jul-Sep;37(3):308-310. doi: 10.4103/JISPPD.JISPPD_340_18.

Congenital insensitivity to pain in a 1-year-old boy.

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Department of Oral Medicine and Radiology, Bapuji Dental College and Hospital, Davangere, Karnataka, India.


Congenital insensitivity to pain (CIP) is a rare autosomal recessive genetic condition which causes reduced pain sensation, thermal sensation, and habit of self-mutilation. It is a life-threatening condition where due to reduced pain sensation, patient might not understand the severity of the injury which can eventually lead to death. Such people live a compromised life and can also affect them psychologically. Here, we are reporting a case of an infant with clinical features suggestive of CIP with a mutation in exon 5 of PRDM12 gene. The child has minimal response to pain along with self-mutilation and mental retardation.


Congenital insensitivity to pain; PRDM12 gene; self-mutilation

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