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Perit Dial Int. 2019 Nov-Dec;39(6):502-508. doi: 10.3747/pdi.2018.00247. Epub 2019 Oct 3.

Effect of Liver Cirrhosis on the Outcomes of Peritoneal Dialysis.

Author information

1
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
2
Department of Internal Medicine, Dongguk University Ilsan Hospital, Gyeonggi-do, Korea.
3
Department of Internal Medicine, Cheju Halla General Hospital, Jeju-do, Korea.
4
Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
5
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea hansway80@gmail.com.

Abstract

Background:Peritoneal dialysis (PD) has become an increasingly important treatment modality for end-stage renal disease. However, application of PD in patients with liver cirrhosis (LC) and subsequent outcomes have not been thoroughly evaluated.Methods:A total of 1,366 patients (≥ 18 years old) who started PD at 4 tertiary referral centers between January 2000 and December 2015 were initially reviewed. Among them, 45 patients with LC were finally analyzed (LC-PD). Using the multivariate Cox hazard ratio (HR) model, outcomes such as technique failure, infection, and mortality in patients with LC-PD were compared with those in non-LC-PD patients (non-LC-PD) or patients with LC who received hemodialysis (LC-HD). All of the patients were selected by 1:1 matching of age, sex, catheter insertion date, and diabetes mellitus.Results:During the mean follow-up duration of 43 ± 35.8 months, 12 patients with LC-PD experienced technique failure, and this rate was similar to that of non-LC-PD patients. In evaluating infection episodes, the most common causes for peritonitis and exit-site infection were Escherichia coli (5.8%) and Staphylococcus aureus (19.3%), respectively; these event rates of LC-PD did not differ from those of non-LC-PD. The all-cause mortality rate of the LC-PD group was not different from that of the non-LC-PD and LC-HD groups.Conclusion:Dialysis outcomes such as technique failure, infection, and mortality are not affected by the presence of LC. Accordingly, PD therapy is a good option in patients with LC.

KEYWORDS:

Mortality; peritonitis; technique failure

PMID:
31582468
DOI:
10.3747/pdi.2018.00247

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