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Cells. 2019 Oct 2;8(10). pii: E1189. doi: 10.3390/cells8101189.

Experimental and Computational Approaches to Direct Cell Reprogramming: Recent Advancement and Future Challenges.

Author information

1
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. rgam@mrc-lmb.cam.ac.uk.
2
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. msung@mrc-lmb.cam.ac.uk.
3
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. apandura@mrc-lmb.cam.ac.uk.

Abstract

The process of direct cell reprogramming, also named transdifferentiation, permits for the conversion of one mature cell type directly into another, without returning to a dedifferentiated state. This makes direct reprogramming a promising approach for the development of several cellular and tissue engineering therapies. To achieve the change in the cell identity, direct reprogramming requires an arsenal of tools that combine experimental and computational techniques. In the recent years, several methods of transdifferentiation have been developed. In this review, we will introduce the concept of direct cell reprogramming and its background, and cover the recent developments in the experimental and computational prediction techniques with their applications. We also discuss the challenges of translating this technology to clinical setting, accompanied with potential solutions.

KEYWORDS:

cell therapy; computational biology; direct reprogramming; regenerative medicine; transdifferentiation

PMID:
31581647
DOI:
10.3390/cells8101189
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