Comparative in vitro activity of norfloxacin and seven other antimicrobial agents against clinical isolates from urinary tract infections

Scand J Infect Dis. 1985;17(1):95-8. doi: 10.3109/00365548509070427.

Abstract

The in vitro activity of norfloxacin, a new quinolone derivative, was tested against 469 clinical isolates derived mainly from urinary samples from outpatients. It inhibited all Escherichia coli, Klebsiella oxytoca and Proteus strains at a concentration of 0.25 micrograms/ml, and all Pseudomonas aeruginosa, Enterobacter, Klebsiella pneumoniae, Staphylococcus and Enterococcus strains at a concentration of 8 micrograms/ml or less. Norfloxacin proved to be more effective than nalidixic acid, trimethoprim, mecillinam and nitrofurantoin against all gram-negative rods tested.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Infective Agents, Urinary / pharmacology*
  • Cefaclor / pharmacology
  • Enterobacteriaceae / drug effects*
  • Enterobacteriaceae Infections / microbiology
  • Humans
  • Microbial Sensitivity Tests
  • Nalidixic Acid / analogs & derivatives*
  • Nalidixic Acid / pharmacology
  • Norfloxacin
  • Penicillins / pharmacology
  • Staphylococcal Infections / microbiology
  • Staphylococcus / drug effects*
  • Streptococcal Infections / microbiology
  • Streptococcus / drug effects*
  • Urinary Tract Infections / microbiology*

Substances

  • Anti-Infective Agents, Urinary
  • Penicillins
  • Nalidixic Acid
  • Cefaclor
  • Norfloxacin