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Biomark Med. 2019 Oct;13(15):1255-1261. doi: 10.2217/bmm-2018-0253. Epub 2019 Oct 3.

Evaluation of neutrophil-lymphocyte ratio in predicting bloodstream infection.

Author information

1
Department of Pharmacy, The Second Xiangya Hospital, Central South University; Institute of Clinical Pharmacy, Central South University, Changsha 410011, PR China.
2
Department of Pharmacy, College of Pharmacy, Central South University, Changsha 410011, PR China.
3
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410078, PR China.

Abstract

Aim: The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in bloodstream infection (BSI) deserves further investigation. Patients & methods: The NLR values were measured and compared in BSI patients and healthy controls. The receiver operating characteristic of NLR and cut-off values were measured in BSI patients and subgroups. Results: We have measured the NLR of study group with 2160 BSI patients and normal group with 2523 healthy controls, which was significantly high in study group (11.36 ± 21.38 vs 2.53 ± 0.86; p < 0.001) and the area under the curve was 0.834 (95% CI: 0.825-0.842; p < 0.001). The critical value of NLR for diagnosis of BSI was 3.09, with a sensitivity of 75.3%, and a specificity of 93.6%. Conclusion: NLR is an effective diagnostic indicator of including BSIs of Gram-negative bacteria, Gram-positive bacteria and fungus.

KEYWORDS:

bloodstream infection; neutrophil-to-lymphocyte ratio; receiver operating characteristic curve

PMID:
31580146
DOI:
10.2217/bmm-2018-0253

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