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Sci Adv. 2019 Sep 25;5(9):eaaw6671. doi: 10.1126/sciadv.aaw6671. eCollection 2019 Sep.

Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations.

Author information

1
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
2
Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany.
3
Center for Systems Biology Dresden, 01307 Dresden, Germany.
4
Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA 92521, USA.
5
Division of Vertebrate Zoology and Sackler Institute for Comparative Genomics, American Museum of Natural History, New York, NY 10024, USA.

Abstract

The transition from land to water in whales and dolphins (cetaceans) was accompanied by remarkable adaptations. To reveal genomic changes that occurred during this transition, we screened for protein-coding genes that were inactivated in the ancestral cetacean lineage. We found 85 gene losses. Some of these were likely beneficial for cetaceans, for example, by reducing the risk of thrombus formation during diving (F12 and KLKB1), erroneous DNA damage repair (POLM), and oxidative stress-induced lung inflammation (MAP3K19). Additional gene losses may reflect other diving-related adaptations, such as enhanced vasoconstriction during the diving response (mediated by SLC6A18) and altered pulmonary surfactant composition (SEC14L3), while loss of SLC4A9 relates to a reduced need for saliva. Last, loss of melatonin synthesis and receptor genes (AANAT, ASMT, and MTNR1A/B) may have been a precondition for adopting unihemispheric sleep. Our findings suggest that some genes lost in ancestral cetaceans were likely involved in adapting to a fully aquatic lifestyle.

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