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J Lab Physicians. 2019 Jul-Sep;11(3):281-283. doi: 10.4103/JLP.JLP_172_18.

Plasma cell neoplasm with varied morphology: A report of two cases.

Author information

1
Department of Pathology, Military Hospital, Nasirabad, Rajasthan, India.
2
Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India.
3
Department of Hematology, Command Hospital (SC), Pune, Maharashtra, India.

Abstract

Plasma cell (PC) neoplasm (PCN) with varied morphology has been described in the literature. The majority of clonal proliferation of PCs is composed of easily recognizable morphology in the bone marrow (BM). However, few cases may cause diagnostic complexity, as they exhibit varied cytological and architectural heterogeneity which may pose problem in morphological diagnosis and require the use of ancillary techniques like immunohistochemistry (IHC). We illustrate here two such cases of PCN with varied morphology in BM aspirate, in the form of clustering/rosetting and multiple clear cytoplasmic vacuoles, respectively, leading to varied differential diagnosis. However, later, the histopathological features on BM biopsy findings were relatively characteristic and IHC confirmed the final diagnosis. The morphological variants documented in both these cases are exceptional and representative of the various forms of atypical PCs.

KEYWORDS:

Bone marrow; immunohistochemistry; morphology; plasma cell neoplasm

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