Bone Marrow: An Immunometabolic Refuge during Energy Depletion

Cell Metab. 2019 Oct 1;30(4):621-623. doi: 10.1016/j.cmet.2019.08.022.

Abstract

An integrated immunometabolic response during negative energy balance is required for host survival. Three new papers by Jordan et al. (2019), Nagai et al. (2019), and Collins et al. (2019) report that monocytes, naive B cells, and memory CD8 T cells use bone marrow as a haven to tide off periods of metabolic adversity to maintain immune-responsiveness.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Bone Marrow Cells
  • Bone Marrow*
  • Fasting
  • Immunity, Mucosal*
  • Monocytes
  • T-Lymphocytes