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Annu Rev Genet. 2019 Oct 2. doi: 10.1146/annurev-genet-112618-043633. [Epub ahead of print]

Organization of Chromosomal DNA by SMC Complexes.

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Laboratory of Molecular Biology, Medical Research Council, Cambridge University, Cambridge CB2 0QH, United Kingdom.
Department of Biochemistry, Oxford University, Oxford OX1 3QU, United Kingdom; email:


Structural maintenance of chromosomes (SMC) complexes are key organizers of chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such as chromosome segregation, chromosome maintenance, sister chromatid cohesion, and mitotic chromosome compaction, it appears that these complexes function via highly conserved mechanisms and that they represent a novel class of DNA translocases. Expected final online publication date for the Annual Review of Genetics, Volume 53 is November 23, 2019. Please see for revised estimates.

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