Format

Send to

Choose Destination
Int J Mol Sci. 2019 Sep 30;20(19). pii: E4865. doi: 10.3390/ijms20194865.

ILC2 Activation by Protozoan Commensal Microbes.

Author information

1
University of Toronto, Department of Immunology, Toronto, ON M5S 1A8, Canada. kyle.burrows@utoronto.ca.
2
University of Toronto, Department of Immunology, Toronto, ON M5S 1A8, Canada. louis.ngai@mail.utoronto.ca.
3
University of Toronto, Department of Immunology, Toronto, ON M5S 1A8, Canada. fl.wong@mail.utoronto.ca.
4
Ranomics, Inc. Toronto, ON M5G 1X5, Canada. fl.wong@mail.utoronto.ca.
5
University of Toronto, Department of Immunology, Toronto, ON M5S 1A8, Canada. taehyoan.won@mail.utoronto.ca.
6
University of Toronto, Department of Immunology, Toronto, ON M5S 1A8, Canada. arthur.mortha@utoronto.ca.

Abstract

Group 2 innate lymphoid cells (ILC2s) are a member of the ILC family and are involved in protective and pathogenic type 2 responses. Recent research has highlighted their involvement in modulating tissue and immune homeostasis during health and disease and has uncovered critical signaling circuits. While interactions of ILC2s with the bacterial microbiome are rather sparse, other microbial members of our microbiome, including helminths and protozoans, reveal new and exciting mechanisms of tissue regulation by ILC2s. Here we summarize the current field on ILC2 activation by the tissue and immune environment and highlight particularly new intriguing pathways of ILC2 regulation by protozoan commensals in the intestinal tract.

KEYWORDS:

ILC2; Trichomonas; Tritrichomonas musculis; commensals; intestinal immunity; mucosal immunity; protozoa; succinate; taste receptors; type 2 immunity

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center