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Medicine (Baltimore). 2019 Sep;98(39):e16788. doi: 10.1097/MD.0000000000016788.

Kuntai capsules improve glucolipid metabolism in patients with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial.

Author information

1
Department of Gynaecology, Institute of Gynecology and Obstetrics of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang.
2
Department of Gynaecology, Nankang District Maternal and Child Health Hospital, Ganzhou.
3
Department of Gynaecology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine.
4
Department of Gynaecology, The Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine.
5
Department of Obsterics and Gynecology, Nanchang Traditional Chinese Medicine Hospital.
6
Department of Gynaecology, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China.

Abstract

BACKGROUND:

The aim of this study was to observe the effect and safety of Heyan Kuntai Capsule (HYKT) on glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS).

METHODS:

Hundred patients with PCOS were randomly divided into HYKT group (n = 50) and placebo groups (n = 50) in which the individuals were treated with HYKT and its placebo continuously for 6 months. Meanwhile, all participants received health education (such as exercise and diet). The primary outcomes were serum sex hormone levels, a series of blood lipid, fasting and postprandial 2 hours blood glucose. Body mass index (BMI), waist-hip ratio (WHR), insulin, homeostatic model assessment of insulin resistance (HOMA-IR), and insulin-sensitive index (ISI) were also observed. In addition, adverse events were recorded to evaluate the drug safety.

RESULTS:

After treatment, the BMI and WHR of all the patients were decreased. The fasting and postprandial 2 hours blood glucose levels were significantly declined when treated with HYKT, which were not observed in the placebo group. Similarly, serum sex hormones including luteinizing hormone (LH), LH/follicle-stimulating hormone (FSH), and testosterone were lowered after treated with HYKT instead of the placebo. Besides, blood lipids outcomes such as total cholesterol, triglyceride, and low-density lipoprotein cholesterol, as well as insulin and HOMA-IR were decreased with significance in HYKT group when compared with those in the placebo group, whereas high-density lipoprotein cholesterol and ISI increased obviously.

CONCLUSION:

HYKT showed the effect on ameliorating the glucose and lipid metabolism disorder and improving insulin resistance and increase insulin sensitivity of PCOS patients, which is similar to insulin sensitizing agent.

PMID:
31574794
DOI:
10.1097/MD.0000000000016788
[Indexed for MEDLINE]
Free PMC Article

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