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Indian J Med Res. 2019 Jul;150(1):23-32. doi: 10.4103/ijmr.IJMR_2055_16.

Adhesion molecules facilitate host-pathogen interaction & mediate Mycobacterium tuberculosis pathogenesis.

Author information

1
Allergy & Infectious Diseases, CSIR-Institute of Genomics & Integrative Biology, Delhi, India.

Abstract

Most of the microorganisms display adhesion molecules on their surface which help them to bind and interact with the host cell during infection. Adhesion molecules help mycobacteria to colonize and invade immune system of the host, and also trigger immune response explicated by the host against the infection. Hence, understanding the signalling pathways illustrated by these molecules to enhance our knowledge on mycobacterial survival and persistence inside the host cell is required. Hence, this review was focussed on the role of adhesion molecules and their receptor molecules. The various mechanisms adopted by adhesion molecules to bind with the specific receptors on the host cell and their role in invasion and persistence of mycobacterium inside the host cell are explained.

KEYWORDS:

Adhesion; Mycobacterium tuberculosis; fibronectin; fibronectin-binding protein; lipoarabinomannan; macrophages; proline glutamic polymorphic CG repetitive sequence

PMID:
31571626
DOI:
10.4103/ijmr.IJMR_2055_16
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