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Acta Neurol Belg. 2019 Dec;119(4):607-613. doi: 10.1007/s13760-019-01214-3. Epub 2019 Sep 30.

Bright light therapy with a head-mounted device for anxiety, depression, sleepiness and fatigue in patients with Parkinson's disease.

Author information

1
Neurology Department, Clinique Saint-Pierre Ottignies, Avenue Reine Fabiola 9, 1340, Ottignies-Louvain-La-Neuve, Belgium.
2
Medical Writer, Andrade-Evrard SPRL, Rue du Moulin 6, 1457, Tourinnes Saint Lambert, Belgium.
3
Nuclear Medicine Department, Grand Hôpital de Charleroi, Grand'Rue 3, 6000, Charleroi, Belgium.
4
Student at Faculté des Sciences de la Motricité, Université Catholique de Louvain, Place Pierre de Coubertin 1, 1348, Louvain-La-Neuve, Belgium.
5
Neurology Department, Clinique Saint-Pierre Ottignies, Avenue Reine Fabiola 9, 1340, Ottignies-Louvain-La-Neuve, Belgium. Frederic.evrard@cspo.be.

Abstract

The beneficial effects of bright light therapy (BLT) on the disabling non-motor symptoms of Parkinson's disease (PD) remain uncertain. The objective of this study was to investigate if daily BLT, with a head-mounted device (Luminette®), has a beneficial effect on depression, anxiety, daytime sleepiness and fatigue in patients with PD. In this double-blind, placebo-controlled study, 16 patients with PD were randomized to receive either 1 month of BLT or 1 month of placebo therapy, separated by a 2-week washout period, in a crossover fashion. Patients completed questionnaires for the Hospital Anxiety and Depression Scale (HADS), the Epworth Sleepiness Scale (ESS) and the Fatigue Impact Scale (FIS) before and after each treatment period. The primary outcome measures were changed from baseline in scores between treatment groups. No significant changes were observed in the HADS anxiety scores and FIS scores after BLT and after placebo. The ESS scores decreased non-significantly only after BLT. A post hoc analysis of patients who had baseline ESS scores > 11 revealed a significantly greater decrease in ESS scores after BLT than after placebo. Future studies investigating the effect of BLT on sleepiness could focus specifically on patients with high ESS scores.

KEYWORDS:

Anxiety; Depression; Parkinson’s disease; Phototherapy; Sleepiness

PMID:
31571135
DOI:
10.1007/s13760-019-01214-3

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