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J Cutan Pathol. 2019 Sep 30. doi: 10.1111/cup.13580. [Epub ahead of print]

A concise review of angiofibroma of soft tissue: A rare newly described entity that can be encountered by dermatopathologists.

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Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine, at Dartmouth, Lebanon, New Hampshire.
Division of Molecular Pathology, The Translational Genomics Research Institute, Phoenix, Arizona and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
First Department of Pathology, Medical School, University of Athens, Athens, Greece.


Angiofibroma of soft tissue (AFST) is a newly described, rare mesenchymal neoplasm with fibroblastic and vascular components; it can be seen in both sexes and in a broad age range. It presents as a slowly enlarging mass, most often in the deep tissues of the upper and lower extremities, but occasionally in a superficial location where it may be encountered by dermatopathologists. It has a benign clinical course with a very low probability of recurrence after complete excision. This lesion has a prominent vasculature and may have an infiltrative growth pattern. These features could lead to a misdiagnosis, such as malignant vascular tumor, by an unwary dermatopathologist. The diagnosis of AFST initially relied solely on morphology and immunohistochemistry but, more recently, molecular studies have begun to play a role. Because of the potential for misdiagnosis, we present this review to raise awareness.


FISH; NCOA2; angiofibroma; soft tissue


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