Format

Send to

Choose Destination
J Cutan Pathol. 2019 Sep 30. doi: 10.1111/cup.13580. [Epub ahead of print]

A concise review of angiofibroma of soft tissue: A rare newly described entity that can be encountered by dermatopathologists.

Author information

1
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine, at Dartmouth, Lebanon, New Hampshire.
2
Division of Molecular Pathology, The Translational Genomics Research Institute, Phoenix, Arizona and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
3
First Department of Pathology, Medical School, University of Athens, Athens, Greece.

Abstract

Angiofibroma of soft tissue (AFST) is a newly described, rare mesenchymal neoplasm with fibroblastic and vascular components; it can be seen in both sexes and in a broad age range. It presents as a slowly enlarging mass, most often in the deep tissues of the upper and lower extremities, but occasionally in a superficial location where it may be encountered by dermatopathologists. It has a benign clinical course with a very low probability of recurrence after complete excision. This lesion has a prominent vasculature and may have an infiltrative growth pattern. These features could lead to a misdiagnosis, such as malignant vascular tumor, by an unwary dermatopathologist. The diagnosis of AFST initially relied solely on morphology and immunohistochemistry but, more recently, molecular studies have begun to play a role. Because of the potential for misdiagnosis, we present this review to raise awareness.

KEYWORDS:

FISH; NCOA2; angiofibroma; soft tissue

PMID:
31568567
DOI:
10.1111/cup.13580

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center