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Neuroreport. 2019 Nov 6;30(16):1068-1073. doi: 10.1097/WNR.0000000000001297.

TOMM40 polymorphism is associated with resting-state functional MRI results in patients with Alzheimer's disease.

Xiao X1, Wei J1, Zhang W1,2, Jiao B1,3,4, Liao X1, Pan C1, Liu X1, Yan X1,3,4, Tang B1,3,4,5,6,7, Zhang Y2, Wang D2, Xing W2, Liao W2, Shen L1,3,4,8.

Author information

1
Departments of Neurology.
2
Radiology.
3
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
4
Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China.
5
Parkinson's Disease Center of Beijing Institute for Brain Disorders, Beijing, China.
6
Collaborative Innovation Center for Brain Science.
7
Collaborative Innovation Center for Genetics and Development, Shanghai, China.
8
Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.

Abstract

OBJECTIVE:

Translocase of outer mitochondrial membrane 40 (TOMM40) encodes translocase of the outer mitochondrial membrane (TOM), which is associated with mitochondrial dysfunction in Alzheimer's disease (AD). TOMM40 rs157581-G has been reported to increase susceptibility to AD. However, the effect of TOMM40 rs157581-G in resting-state functional MRI (rs-fMRI) on AD has not been studied. Therefore, we aimed to investigate the role of TOMM40 rs157581-G on rs-fMRI results in AD patients.

METHODS:

Twenty-four AD patients were divided into two groups based on TOMM40 rs157581-G status, and clinical and imaging data were compared between the groups.

RESULTS:

TOMM40 rs157581-G carriers of AD showed decreased regional homogeneity in the left precuneus and decreased amplitude of low-frequency fluctuations in the bilateral temporal poles compared with noncarriers of AD. TOMM40 rs157581-G carriers of AD also showed increased functional connectivity between the right middle occipital gyrus and the left supramarginal gyrus and decreased connectivity between the left superior occipital gyrus and the right transverse temporal gyrus in comparison with TOMM40 rs157581-G noncarriers.

CONCLUSION:

We analyzed rs-fMRI characteristics of TOMM40 rs157581-G carriers of AD for the first time, which suggest that TOMM40 rs157581-G plays a harmful role in AD patients.

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