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J Hepatobiliary Pancreat Sci. 2019 Sep 30. doi: 10.1002/jhbp.677. [Epub ahead of print]

Influence of duration of type 1 diabetes on long-term pancreatic transplant outcomes.

Author information

1
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
2
Zhejiang Provincial Collaborative Innovation Center of Agricultural Biological Resource Biochemical Manufacturing, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, Zhejiang Province, China.
3
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, Zhejiang Province, China.
4
Division of Hepatobiliary and Pancreatic Surgery, Yiwu Central Hospital, Yiwu, Zhejiang Province, China.

Abstract

BACKGROUND:

There are no multicenter studies on the influence of diabetes duration on pancreatic transplant outcomes. Our study aimed to determine how type 1 diabetes duration influenced survival of pancreatic grafts.

METHODS:

The data of 8,139 patients received pancreas transplants during 2006-2015 were extracted from the Scientific Registry of Transplant Recipients database. Patients were separated into two groups according to duration of diabetes: S group (diabetes ≤20 years) and L group (>20 years).

RESULTS:

Compared to S group, L group were older and prone to be male, to have higher BMI, to receive pancreas after kidney (PAK) transplantation, and to be White. Patient survival was not significantly different between the two groups, but pancreatic survival was better in the L group (HR = 0.88; p = 0.012). Pancreatic survival of L group was better than S group in pancreas transplant alone (PTA) and simultaneous pancreas-kidney (SPK). Graft survival was not significant different between the two groups in PAK. Diabetes duration was an independent predictor of graft survival in SPK patients (HR = 0.86; p = 0.012).

CONCLUSIONS:

Diabetes duration has no influence on patient survival. However, long duration of T1DM appears to be protective against pancreatic graft loss.

KEYWORDS:

Duration of diabetes; Outcome; Pancreas transplantation; Predictor; Type 1 diabetes mellitus

PMID:
31566900
DOI:
10.1002/jhbp.677

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