Format

Send to

Choose Destination
Brain Behav Immun. 2020 Jan;83:120-125. doi: 10.1016/j.bbi.2019.09.021. Epub 2019 Sep 26.

Experienced homophobia and gene expression alterations in Black and Latino men who have sex with men in Los Angeles County.

Author information

1
Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, United States; Center for Behavioral and Addiction Medicine, Department of Family Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States; Department of Family Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States. Electronic address: mjli@mednet.ucla.edu.
2
National Clinician Scholars Program UCLA, Division of General Internal Medicine and Health Services Research, Department of Medicine, Los Angeles, CA, United States; Veterans Affairs, Health Services Research & Development, Center for the Study of Healthcare Innovation, Implementation & Policy, Los Angeles, CA, United States.
3
Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, United States; Center for Behavioral and Addiction Medicine, Department of Family Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States; Department of Family Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States.
4
Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, United States; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, United States.
5
Center for Behavioral and Addiction Medicine, Department of Family Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States; Department of Family Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States.
6
Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States.

Abstract

Men who have sex with men (MSM) experience high rates of homophobic victimization, which is linked to myriad chronic physical and mental health disparities. Social adversity such as rejection, isolation, and racial discrimination can induce a conserved transcriptional response to adversity (CTRA) involving upregulation of proinflammatory genes and downregulation of type I interferon and antibody synthesis genes. This study specifically examines whether homophobic victimization is associated with expression of CTRA profiles in Black and Latino MSM living in Los Angeles. Analyses linked behavioral survey data with quantified RNA from leukocytes from blood samples of 70 participants over 12 months. CTRA gene expression was increased by 3.1-fold in MSM who experienced homophobic victimization while adjusting for major leukocyte subsets and sociodemographics. Accounting for all these factors, CTRA gene expression was significantly enhanced in MSM who identified as Black compared to Latino. Our findings identify experiences of homophobic victimization as drivers of inflammatory and type I interferon gene expression profiles, which can contribute to physical and mental health challenges in Black and Latino MSM.

KEYWORDS:

Gene expression; Homophobia; Immune system; Inflammation; Men who have sex with men; Transcriptome; Victimization

PMID:
31563693
PMCID:
PMC6906252
[Available on 2021-01-01]
DOI:
10.1016/j.bbi.2019.09.021

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center