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Mol Cell. 2019 Oct 17;76(2):320-328. doi: 10.1016/j.molcel.2019.08.025. Epub 2019 Sep 25.

Human Germline Cell Development: from the Perspective of Single-Cell Sequencing.

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1
Beijing Advanced Innovation Center for Genomics (ICG), Biomedical Pioneering Innovation Center (BIOPIC), College of Life Sciences, Peking University, Beijing 100871, China. Electronic address: wenlu@pku.edu.cn.
2
Beijing Advanced Innovation Center for Genomics (ICG), Biomedical Pioneering Innovation Center (BIOPIC), College of Life Sciences, Peking University, Beijing 100871, China. Electronic address: tangfuchou@pku.edu.cn.

Abstract

Germline cells are the beginning of new individuals in multicellular animals, including humans. Our understanding of these cell types is limited by the difficulty of analyzing the precious and heterogeneous germline tissue samples. The rapid development of single-cell sequencing technologies provides a chance for comprehensive profiling of the omics dynamics of human germline development. In this review, we discuss progress in analyzing the development of human germline cells, including preimplantation and implantation embryos, fetal germ cells (FGCs), and adult spermatogenesis by single-cell transcriptome and epigenome sequencing technologies.

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