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Hum Immunol. 2019 Sep 25. pii: S0198-8859(18)31187-X. doi: 10.1016/j.humimm.2019.09.009. [Epub ahead of print]

Th9 cytokines curb cervical cancer progression and immune evasion.

Author information

1
Division of Molecular Genetics & Biochemistry, ICMR-National Institute of Cancer Prevention and Research, Noida, India.
2
CSIR-Institute of Genomics and Integrative Biology, Delhi, India. Electronic address: kausik@igib.in.
3
Division of Molecular Genetics & Biochemistry, ICMR-National Institute of Cancer Prevention and Research, Noida, India. Electronic address: Mausumi.bharadwaj@gov.in.

Abstract

Cervical cancer is one of the most common cancers among women in developing countries. Persistent infection with high-risk human papillomavirus (HPV) is the major determinant for the development of cervical cancer. Role of newly discovered T helper 9 (Th9) cells in cervical cancer pathogenesis is yet unfolded. In this study, we observed a huge infiltration of PU.1+ cells and overrepresentation of IL-9R in tissue biopsy specimens of CIN patients in cervical cancer cases. Treatment with Th9 signatory cytokines, IL-9 and IL-21, suppressed proliferation, enhanced apoptosis and stimulated the expression of MHC I and e-cadherin on HeLa cell lines. Th9 thus seems enhance antitumor immune response through T cell cytotoxicity and play crucial role in a controlling malignant cell transformation. Therefore, this study helps in firmer understanding of relevance of Th9 in cervical cancer immunity.

KEYWORDS:

Antitumor; Cervical cancer; IL-21; IL-9; PU.1(+) cells; TILs; Th9 cells

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