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Med Sci Monit. 2019 Sep 28;25:7289-7294. doi: 10.12659/MSM.916466.

Two-Dimensional Speckle Tracking Versus Applanation Tonometry in Evaluation of Subclinical Atherosclerosis in Children with Type 1 Diabetes Mellitus.

Author information

1
Department of Diagnostic Imaging, Polish Mothers' Memorial Hospital Research Institute, Łódź, Poland.
2
Department of Pediatrics and Immunology with Nephrology Unit, Polish Mothers' Memorial Hospital Research Institute, Łódź, Poland.
3
Department of Neurology, Polish Mothers' Memorial Hospital Research Institute, Łódź, Poland.
4
Department of Endocrinology and Metabolic Diseases, Polish Mothers' Memorial Hospital Research Institute, Łódź, Poland.

Abstract

BACKGROUND Patients with type 1 diabetes mellitus (T1DM) often develop atherosclerosis at an early age. In the subclinical stage of the process, minimal/non-morphological changes can be noticed, but the arterial wall function can be impaired. Applanation tonometry allows to assess the arterial tree stiffness; however, the Two-Dimensional Speckle Tracking (2DST) is an increasingly accepted alternative. This study evaluated arterial wall stiffness using these 2 techniques in children with T1DM. MATERIAL AND METHODS We performed applanation tonometry and carotid arteries sonography with evaluation of the carotid intima-media thickness (cIMT) and use of the 2DST in 50 children with T1DM and in 50 healthy sex- and age-matched controls. We also assessed the reliability of 2DST in 10 random subjects. RESULTS Children with T1DM had increased arterial wall stiffness, which was confirmed by tonometry (PWV: p=0.0386) and 2DST (Strain: p=0.0004; Strain rate: p=0.0081). There was no significant difference in cIMT between groups (0.45±0.06 vs. 0.43±0.05, p=0.073 in children with T1DM and controls, respectively). 2DST presented good intraclass correlation coefficient between researchers and within a single researcher. CONCLUSIONS Children with T1DM presenting with subclinical stage of atherosclerosis were found to have arterial wall stiffening. The 2DST, the same as applanation tonometry, allows to recognize this condition but in a more accessible and reproducible manner.

PMID:
31562737
DOI:
10.12659/MSM.916466

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